By Drew Provan
This ABC has demonstrated itself as a favored advent to medical Haematology, proper either for postgraduate scholars and first care practitioners. Now in its 3rd variation, the ABC of medical Haematology has been completely revised, that includes the newest remedies for leukemia, antithrombotics and medicine for lymphoma and overlaying the newest advances in hematology and bone marrow transplantation. With every one bankruptcy written by way of experts of their respective fields, this is often a fantastic simple textual content for common perform and health facility employees with sufferers who've blood comparable difficulties, particularly GPs, hematology nurses, junior medical professionals, hematologists, and trainees in hematology.
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Extra resources for ABC of Clinical Haematology, 3rd Edition (ABC Series)
New England Journal of Medicine 1999; 341: 1051–62. Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. New England Journal of Medicine 2006; 12: 166–78. Tauro S, Craddock C, Peggs K et al. Allogeneic stem cell transplantation using a reduced intensity conditioning (RIC) regimen has the capacity to produce durable remissions and long term disease free survival in patients with high risk acute myeloid leukemia (AML) and myelodysplasia (MDS). Journal of Clinical Oncology 2005; 23: 9387–93.
The success of such an intensive treatment strategy is predictable at the time of relapse by three main factors: patient age, cytogenetics and duration of first remission. In patients whose duration of first remission is < 1 year, long-term survival rates even with intensive treatment are < 10%, and this information is clearly important when coming to a decision with the patient on whether to proceed down such an arduous road. Novel therapies There is clearly a need for the development of new treatments in AML.
For those patients with myeloid transformations, drugs suitable for treating acute myeloid leukaemia will control the leukaemic proliferation for a time. About 30% of patients will achieve a second chronic phase compatible with a normal lifestyle for months or years. Patients with lymphoid transformations should be treated with drugs appropriate to adult acute lymphoblastic leukaemia. Second chronic phase may be achieved in 40–60% of cases, more commonly in those who had a short interval from diagnosis to transformation.