By Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)
The courting among angiotensin II and high blood pressure used to be demonstrated in 1898 whilst angiotensin II used to be proven to modulate systemic blood strain. Over the intervening a long time, a whole characterization of the renin-angiotensin method (RAS) has been accomplished, and our knowing of its biochemistry and body structure has ended in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists in a position to controlling high blood pressure. extra lately, it used to be proven that angiotensin II is secreted inside of definite tissues and that those tissue-specific platforms function independently of the systemic RAS. the radical idea that angiotensin II regulates a few cardiovascular techniques which are unrelated to blood strain has renewed the curiosity of either easy and medical scientists in angiotensin II. The organization among angiotensin II and cardiac progress, particularly, has indicated that remedies at the moment in use for high blood pressure could have direct program to the remedy of middle failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg used to be convened October 18-20, 1996 to envision the medical and uncomplicated features of angiotensin receptor biology as they follow to high blood pressure and middle failure. furthermore, the aptitude remedy of those stipulations utilizing particular angio tensin receptor antagonists was once addressed in the context in their speedy healing program and destiny potential.
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For their generous donation in support of the Manitoba Cardiovascular Forum as well as publication of this book. Special thanks are due to Mr. Robert Holland and Ms. Melissa Ramondetta and their editorial staff at Kluwer Academic Publishers for their patience, interest, and hard work in assembling this volume. The help of Ms. Susan Zettler for the preparation of this book is highly appreciated. A. PHARMACOLOGICAL INTERRUPTION OF RENIN-ANGIOTENSIN IN HYPERTENSION PHARMACOLOGICAL INTERRUPTION OF THE RENIN SYSTEM AND THE KIDNEY: LESSONS FROM COMPARATIVE PHARMACOLOGY NORMAN K.
This possibility is strongly supported by a recent study  on the relationship between AGT genotype and the renovascular response to Ang II in caucasians. Plasma AGT did not vary with genotype, but renal vascular responsiveness did. Specifically, normal subjects and patients with hypertension who are homozygous for threonine at codon-235(TT) showed a blunted renovascular response to Ang II despite a high salt diet, which is indicative of nonmodulation. This polymorphism can account for the unusual responses to ACE inhibitors and calcium channel blocking agents in the normotensive offspring described above.
Boniface General Hospital of Winnipeg and continues to serve on a variety of national committees of both governmental and nongovernmental bodies and agencies concerned with health care, higher education, and research. He is a director of several private corporations, and as founding Chairman of the North Portage Development Corporation, he spearheaded the largest urban redevelopment program in Manitoba's history. Dr. Naimark has received several awards and distinctions including appointment as an Officer of the Order of Canada, the award of honorary degrees, the Ben Gurion University of the Negev Distinguished Service Award, the G.