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By Bennie I Osburn; Ronald D Schultz

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PERRYMAN bility to bacterial infections. C-HS in cattle occurs in Herefords which are easily recognized by the dilution of coat color and the presence of large cytoplasmic granules within neutrophils and several other cell types (Padgett et al, 1964). The basis for the increased susceptibility to pyogenic infections in cattle with C-HS has been investigated by Renshaw et al. (1974) who found the ability of neutrophils to ingest bacteria was normal. Intracellular bacterial killing, however, was abnormal, occurring at a slower rate than in normal neutrophils.

Classification as a primary or secondary disorder implies a mechanistic basis in the characterization of the disease. A primary dis­ order is one in which a genetic basis is proven or suspected. A secondary disorder is one in which the animal was initially capable of producing normal defense responses. However, because of a mechanical problem, disease, or treatment, the response capacity of the animal is now sup­ pressed or depleted. Examples of secondary deficiencies include malnu­ trition, irradiation, failure of the newborn to absorb colostral Ig, treat­ ment with corticosteroids, neoplasia, and infection by immunosuppressive agents.

1968). Scand. J. Clin. Lab. Invest. 2 1 , 77-89. Brandenburg, A. , and Wilson, M. R. (1973). Immunology 24, 119-127. , and Andresen, E. (1971). Ada Pathol. Microbiol. , Sect. A 79, 686-687. Bryans, J. , Swerczek, T. , Darlington, R. , and Crowe, M. W. (1977). J. Equine Med. Sur g. 1, 20-26. Buening, G. , Perryman, L. , and McGuire, T. ,C. (1977). J. Am. Vet. Med. Assoc. 171, 455-458. Buening, G. , Perryman, L. , and McGuire, T. C. (1978). Infect. Immun. 19, 695-698. Campbell, S. G. (1974). Br.

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