Biotechnology

Download Bioreactor Systems for Tissue Engineering by D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr. PDF

By D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr. Cornelia Kasper, Prof. Martijn van Griensven, Dr. Ralf Pörtner (eds.)

The editors of this detailed quantity might first wish to thank all authors for his or her very good contributions. we'd additionally prefer to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for delivering the chance to compose this quantity and Springer for organizational and technical help. Tissue engineering represents one of many significant rising fields in smooth b- expertise; it combines assorted matters starting from organic and fabric sciences to engineering and scientific disciplines. the purpose of tissue engineering is the improvement of healing methods to alternative diseased organs or tissues or increase their functionality. as a result, 3 dimensional biocompatible fabrics are seeded with cells and cultivated in appropriate structures to generate practical tissues. many various features play a task within the formation of 3D tissue buildings. within the first position the resource of the used cells is of the maximum value. to avoid tissue rejection or immune reaction, preferentially autologous cells are actually used. specifically, stem cells from assorted resources are gaining unheard of value as they are often differentiated into diversified tissues through the use of distinct media and supplementations. within the box of biomaterials, various scaffold fabrics exist already yet new composites also are being built in accordance with polymeric, normal or xenogenic assets. additionally, a crucial factor in tissue en- neering is the formation of tissues less than good outlined, managed and reprod- ible stipulations. consequently, a considerable variety of new bioreactors were developed.

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While manufacturing a product at central locations has the clear advantage of enabling close supervision over the entire production process, this requires establishing and maintaining large and expensive GMP facilities. , packaging, shipping, and tracking of living biopsies and engineered grafts), and the considerable associated expenses, must be considered for the centralized production of engineered tissue grafts. , ACTES), could be located on-site within the confines of a hospital. This would eliminate complex logistical issues of transferring biopsies and engineered products between locations, eliminate the need for large and expensive GMP tissue engineering facilities, facilitate scale-up, and minimize labor-intensive operator handling.

Nevertheless, despite this early effort to automate the tissue engineering process, the production system was not highly controlled and resulted in many batches that were defective, ultimately contributing to the overall high production costs [2]. Considering that significant problems were encountered in the manufacturing of this allogenic product, tremendous challenges clearly lie ahead in order to automate and scale the production 22 D. Wendt et al. of autologous grafts (technically, biologically, and in terms of regulatory issues), particularly since cells from each patient will be highly variable and cells must be processed as completely independent batches.

83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. 94. 1007/10_2008_11 © Springer-Verlag Berlin Heidelberg 2009 29 Bioreactor Technology in Cardiovascular Tissue Engineering H. Mertsching and J. Hansmann Abstract Cardiovascular tissue engineering is a fast evolving field of biomedical science and technology to manufacture viable blood vessels, heart valves, myocardial substitutes and vascularised complex tissues. In consideration of the specific role of the haemodynamics of human circulation, bioreactors are a fundamental of this field.

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