By Karl Schügerl
This quantity covers tracking of the biotechnological procedure with subtle analytical recommendations, use of the ensuing facts through mathematical versions, and computer-aided keep an eye on for development of the productiveness of biotechnological tactics. The e-book comprises 4 major elements: tools for research and biosensoring, measuring ideas, approach versions and their automation and keep an eye on. using various phone varieties, recombinant microorganisms, and reactor stipulations are provided and all current thoughts of tracking and optimizing cellphone progress and product formation are mentioned with reference to more advantageous productiveness. themes integrated are: equipment and tools/ Biosensors/ Characterization of Bioreactors/ decision of telephone focus/ phone types/ Stirred Tank types/ Tower Reactor versions/ approach types/ keep an eye on of Bioreactor structures/ Automation/ regulate of Downstream Processing
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Extra resources for Biotechnology, 2nd Edition, Volume 4: Measuring, Modelling and Control
4th Eur. Congr. BioR. ,VANDERMEER, ~,O. LUYBEN,K. CH. A. ), Vol. 3, pp. 153154. Amsterdam: Elsevier Science Publisher B. V. Mou, D. , COONEY,C. L. (1983), Growth monitoring and control in complex medium: A case study employing fed-batch penicillin fermentation and computer-aided on-line mass balancing, Biotechnol. Bioeng. 25, 257-269. , HECKENBACH,M. , Vol. 2, pp. 431-512. Berlin-Heidelberg-New York: Springer Verlag. , WERNER,U. forderung. Projekte 1978-1984, pp. 39-53. Bonn: BMFT (Bundesministerium fur Forschung und Technologie) .
Eng. 4, 226-241. LEE, Y. , TSAO, G. T. (1979), Dissolved oxygen electrodes, Adv. Biochem. Eng. 13, 35-86. , BONALY,R. (1988), Effect of control of pH on the excretion of acid phosphatase by Rhodotorula glutinis, Appl. Microbiol. Biotechnol. 29, 579-585. LEES, F. P . (1976), The reliability of instrumentation, Chem. Ind. (9,195-205. LEHN, J. M. (1988), Supramolekulare Chemie Molekiile, Ubermolekiile und molekulare Funktionseinheiten, Angew. Chem. 100, 91-1 16. , VACEK,V. (1986), Recommended procedure for the measurement of the volumetric mass transfer coefficient kLa in aerated agitated vessels.
It is shown by Henry’s law, Eq. (3). Some compensation may be caused by smaller bubbles, due to compression, at the bottom of the column. 5. It is possible to estimate the local dissolved oxygen concentration during normal fermentation conditions by equating the oxygen uptake rate to the oxygen transfer rate at any position in the vessel. Thus, this balance can be applied to an element of gas and liquid volume at any depth in the reactor. Assuming that the biomass concentration and factors which influence Qo,are uniform within the vessel (no local substrate or oxygen limitation), the oxygen uptake rate may be taken as a constant throughout the vessel.