Biotechnology

Download Biotechnology 2020: From the Transparent Cell to the by G. Kreysa, Rudiger Marquardt PDF

By G. Kreysa, Rudiger Marquardt

This ebook forecasts attainable functions of biotechnology from now to 2020. The forecasts are in accordance with the present nation of clinical wisdom and describe hugely most probably advancements. The shift in the direction of a eu knowledge-based bio-economy relies on the facility to control organic assets in a sustainable demeanour, and to use the advances in microbial, plant and animal biotechnologies to create new, eco-efficient and aggressive services.

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By combining this with new, more selective synthesis strategies, we should also be able to insert important functional groups (pharmacophores) into existing skeletons. Automated genetic algorithms will be used to direct genetic mutation and synthetic modifications so as to optimise biological activity, and this will enable natural products to play a more important role as scaffolds for drug development. The ultimate objective is the creation of a “biological chemical factory for active ingredients” where biologists, chemists, molecular geneticists, bioinformaticians, pharmacologists, doctors and process engineers will work together to quickly produce highly effective and well tolerated drugs for previously incurable diseases.

Thanks to international collaboration and a series of automated measuring processes it should be possible over the coming years to identify and analyse hundreds of proteins and to determine their role in various diseases. A range of screening technologies such as transcript profiling, protein interaction screening and the screening of molecule libraries will improve our understanding of the molecular biology of the brain and will identify new targets for drug development. Damage to this area in the speech-dominant brain hemisphere is often associated with speech disorders.

PET scanning enables complex patterns of chemical activity to be measured in vivo and a threedimensional map to be produced. In the example presented (see image at top of following page) the target molecule is the adenosine A1 receptor. This receptor plays a particularly important role in the interruption of the blood supply caused by a heart attack and in epilepsy. It can also have a neuroprotective effect. It is therefore particularly useful in the case of many neurological disorders to determine whether the Subjects who have learned a second language later in life use different brain areas for grammar tasks in this language when compared to a language learned as a child.

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