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By Steve Olson

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Pp. 121-131 in Biotechnology and Biological Frontiers, Philip H. Abelson, ed. : American Association for the Advancement of Science. Winston J. Brill. 1981. " Scientific American 245(Sep- tember):198-215. National Research Council, Board on Agriculture. 1984. Genetic Engineering of Plants: Agricultural Research Opportunities and Policy Concerns. : National Academy Press. National Research Council, Committee on Biosciences Research in Agriculture. 1985. New Directions for Biosciences Research in Agriculture.

For instance, David, the famous "Bubble Boy" (shown here at age 5), lived 12 years in isolated living quarters. By infecting the defective bone marrow cells of such patients with genetically engineered viruses containing the gene that codes for ADA, researchers hope to cure the disease. year, making this the most common of the initial candidates for gene therapy. However, the neurological component of Lesch-Nyhan disease is caused by a lack of HPRT in the brain, and it is not known if supplying the enzyme from the bone marrow will overcome this deficit.

Thomas E. Wagner. 1984. The Implications of Genetic Engineering in Livestock Production. Knoxville: University of Tennessee. 4 Human Gene Therapy THE EARLY 1970s an American researcher named Stanfield Rogers infected three German girls who lacked the enzyme arginase with Shope papilloma virus, hoping that the virus would transfer to the girls the gene for the missing enzyme. In 1980 Martin Cline of the University of California at Los Angeles exposed the bone marrow of two patients from Italy and Israel who suffered from beta-thalassemia (a blood disorder resembling sickle cell anemia) to recombinant DNA coding for the blood protein hemoglobin, hoping that the bone marrow would incorporate the new genes and alleviate the patients' disease.

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