By Zhihong Xu (auth.), Zhihong Xu, Jiayang Li, Yongbiao Xue, Weicai Yang (eds.)
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Extra resources for Biotechnology and Sustainable Agriculture 2006 and Beyond: Proceedings of the 11th IAPTC&B Congress, August 31-18, 2006 Beijing, China
1999). Two of three volunteers who were given two 150-g doses of transgenic lettuce containing about 2 µg of the antigen per dose, produced protective serum antibodies after the second dose, although the titers declined in a few weeks. Even so, the study confirmed that naïve subjects could be seroconverted by the oral delivery of a plantderived viral antigen. , 2000). Of 33 participants given either two or three 1-mg doses of the antigen, about half showed increased serum IgG titers against the virus.
For this reason, the product was developed using a virus expression vector in tobacco, which allows the rapid production of milligrams of product. Most recently, the Cuban regulatory agencies have approved the production and use of a plant-derived antibody against hepatitis B virus. , the HBV surface antigen. Because it is used in a biopharmaceutical manufacturing process, the antibody has to meet all the same purity and homogeneity criteria imposed on the product itself. Vaccine candidates Plant-derived vaccines can be divided into two categories – those designed for veterinary use and those designed for medical use.
This issue has been reviewed by Gomord et al. (2004). Facing the Future with Pharmaceuticals from Plants 25 Medium and process development for plant cell cultures Since the first approved PDP product was made in cultured tobacco cells, it is interesting to note recent developments in the productivity of plant cell cultures. 5 µg L−1 to 200 mg L−1 based on the culture volume. However, different experiments are very difficult to compare because extraction procedures and the methods used to determine protein concentration are also variable.