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By Eric S. Grace

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1992) Obscurolides, a novel class of phosphodiesterase inhibitors from Streptomyces. I. Production, isolation, structural elucidation and biological activity of obscurolides A1 to A4. J. Antibiot. 45, 1096–1107. 44. , Metzger, J. , and Freund, S. (1994) 5-Phenylpentadienoicacid derivatives from Streptomyces sp. Helv. Chim. Acta 77, 569–574. 45. , and Zähner, H. (1986) Isolierung und Strukturaufklärung von Differolid. Helv. Chim. Acta 69, 1833–1836. 46. , and Zähner, H. (1988) (2S,3R,4R,6R)-2,3,4-Trihydroxy-6-methylcyclohexanon aus zwei ActinomycetenStämmen.

P. (1986) Identification of new elloramycins, anthracycline-like antibiotics, in biological cultures by high-performance liquid chromatography and diode array detection. J. Chromatogr. 361, 432–436. 59. -P. (1988) Tetracenomycins B3 and D3, key intermediates of the elloramycin and tetracenomycin C biosynthesis. J. Antibiot. 41, 1066–1073. 60. , and Zähner, H. (1988) Phenazines from Streptomyces antibioticus strain TÜ 2706. J. Antibiot. 41, 1542–1551. 61. König, W. , and Zähner, H. (1996) Drei neue Aminosäuren aus dem Nikkomycin-Komplex – Strukturaufklärung und Synthese.

The main compounds, naphtherythrins A and B show a biological activity against Gram-positive bacteria and a weak activity against fungi. Under the same conditions Streptomyces exfoliates Tü 1424 produced a group of three new naphthoquinone antibiotics named exfoliamycins [54, 55]. They inhibit growth of Gram-positive bacteria, whereas Gram-negative bacteria and fungi are not sensitive against these antibiotics. The structures of secondary metabolites produced during polystyrene resin fermentations are summarised in Fig.

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