Download Click Chemistry for Biotechnology and Materials Science by Joerg Lahann PDF

By Joerg Lahann

Mimicking traditional biochemical strategies, click on chemistry is a modular method of natural synthesis, becoming a member of jointly small chemical devices speedy, successfully and predictably. not like complicated conventional synthesis, click on reactions supply excessive selectivity and yields, near-perfect reliability and unprecedented tolerance in the direction of a variety of sensible teams and response stipulations. those ‘spring loaded’ reactions are completed by utilizing a excessive thermodynamic motive force, and are attracting super recognition in the course of the chemical neighborhood. initially brought with the point of interest on drug discovery, the idea that has been effectively utilized to fabrics technological know-how, polymer chemistry and biotechnology.

the 1st e-book to think about this topic, click on Chemistry for Biotechnology and fabrics Science examines the basics of click on chemistry, its program to the perfect layout and synthesis of macromolecules, and its quite a few purposes in fabrics technological know-how and biotechnology.  The ebook surveys the present examine, discusses rising tendencies and destiny functions, and offers a big nucleation element for learn.

Edited by means of one of many most sensible a hundred younger innovators with the best strength to have an effect on know-how within the 21st century based on expertise evaluate and with contributions from pioneers within the box, Click Chemistry for Biotechnology and fabrics Science offers an incredible reference for someone eager to research extra approximately click on reactions.

Chapter 1 click on Chemistry: A common Ligation approach for Biotechnology and fabrics technological know-how (pages 1–7): Joerg Lahann
Chapter 2 universal Synthons for click on Chemistry in Biotechnology (pages 9–28): Christine Schilling, Nicole Jung and Stefan Brase
Chapter three Copper?Free click on Chemistry (pages 29–51): Jeremy M. Baskin and Carolyn R. Bertozzi
Chapter four Protein and Peptide Conjugation to Polymers and Surfaces utilizing Oxime Chemistry (pages 53–68): Heather D. Maynard, Rebecca M. Broyer and Christopher M. Kolodziej
Chapter five The function of click on Chemistry in Polymer Synthesis (pages 69–88): Jean?Francois Lutz and Brent S. Sumerlin
Chapter 6 Blocks, Stars and Combs: advanced Macromolecular structure Polymers through click on Chemistry (pages 89–117): Sebastian Sinnwell, Andrew J. Inglis, Martina H. Stenzel and Christopher Barner?Kowollik
Chapter 7 click on Chemistry on Supramolecular fabrics (pages 119–175): Wolfgang H. Binder and Robert Sachsenhofer
Chapter eight Dendrimer Synthesis and Functionalization by way of click on Chemistry for Biomedical functions (pages 177–193): Daniel Q. McNerny, Douglas G. Mullen, Istvan J. Majoros, Mark M. Banaszak Holl and James R. Baker
Chapter nine Reversible Diels–Alder Cycloaddition for the layout of Multifunctional community Polymers (pages 195–215): Amy M. Peterson and Giuseppe R. Palmese
Chapter 10 click on Chemistry within the guidance of Biohybrid fabrics (pages 217–254): Heather J. Kitto, Jan Lauko, Floris P. J. T. Rutjes and Alan E. Rowan
Chapter eleven sensible Nanomaterials utilizing the Cu?Catalyzed Huisgen Cycloaddition response (pages 255–289): Sander S. van Berkel, Arnold W. G. Nijhuis, Dennis W. P. M. Lowik and Jan C. M. van Hest
Chapter 12 Copper?Catalyzed ‘Click’ Chemistry for floor Engineering (pages 291–307): Himabindu Nandivada and Joerg Lahann
Chapter thirteen click on Chemistry in Protein Engineering, layout, Detection and Profiling (pages 309–325): Daniela C. Dieterich and A. James Link
Chapter 14 Fluorogenic Copper(I)?Catalyzed Azide–Alkyne Cycloaddition Reactions and their functions in Bioconjugation (pages 327–353): Celine Le Droumaguet and Qian Wang
Chapter 15 Synthesis and Functionalization of Biomolecules through click on Chemistry (pages 355–378): Christine Schilling, Nicole Jung and Stefan Brase
Chapter sixteen remarkable Electro?Optic homes in Polymers and Dendrimers Enabled by way of click on Chemistry in accordance with the Diels–Alder Reactions (pages 379–398): Jingdong Luo, Tae?Dong Kim and Alex K.?Y. Jen

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Franke, C. Doll, J. , 46, 4479–4482. (19) C. W. Tornoe, C. Christensen, M. Meldal, (2002), Peptidotriazoles on solid phase: [1,2,3]triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides, J. Org. , 67, 3057–3064. (20) O. Roy, S. Faure, V. Thery, C. Didierjean, C. Taillefumier, (2008), Cyclic β-peptoids, Org. , 10, 921–924. P1: OTA c02 JWBK375-Lahann August 12, 2009 17:41 Printer: Yet to come Common Synthons for Click Chemistry in Biotechnology 27 (21) J.

J. Arnusch, H. Branderhorst, B. de Kruijff, R. M. J. Liskamp, E. Breukink, R. J. Pieters, (2007), Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides, Biochemistry, 46, 13437–13442. (24) V. Haridas, K. Lal, Y. K. , 48, 4719–4722. (25) D. T. S. Rijkers, G. W. van Esse, R. Merkx, A. J. Brouwer, H. J. F. Jacobs, R. I. Pieters, R. M. I. Liskamp, (2005), Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry, Chem.

A. Burley, J. Gierlich, M. R. Mofid, H. Nir, S. Tal, Y. Eichen, T. Carell, (2006), Directed DNA metallization, J. Am. Chem. , 128, 1398–1399. (36) J. Gierlich, G. A. Burley, P. M. E. Gramlich, D. M. Hammond, T. Carell, (2006), Click chemistry as a reliable method for the high-density postsynthetic functionalization of alkyne-modified DNA, Org. , 8, 3639–3642. (37) C. T. Wirges, P. M. E. Gramlich, K. Gutsmiedl, J. Gierlich, G. A. Burley, T. Carell, (2007), Pronounced effect of DNA hybridization on click reaction efficiency, QSAR Comb.

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