Download Clinical Lipidology: A Companion to Braunwald's Heart by Christie M. Ballantyne MD PDF

By Christie M. Ballantyne MD

Dr. Ballantyne-one of the most important lipid specialists on the planet and recruited by means of Dr. Braunwald's middle ailment editorial team-together with a stellar solid of participants offers the entire clinical and medical info you want to successfully deal with each element of dyslipidemia. From simple technological know-how to pathogenesis of atherothrombotic affliction to danger overview and the most recent remedy innovations, this new name within the Braunwald's center affliction relatives bargains exceptional updated insurance and professional information on lipidology in a simple, available, and undemanding variety. Plus, professional seek advice performance offers each time, at any place entry to the whole textual content on-line. . comprises complete textual content on-line entry at . good points the services of 1 of the major specialists within the box, making sure you get authoritative information with the main definitive wisdom on hand. . comprises broad clinically correct details protecting probability review, remedy, targeted sufferer populations, and experimental remedies, together with concentrating on HDL that will help you successfully deal with any demanding situations you face. . makes use of remedy algorithms for simple entry to key content material. . provides present perform directions that help in the decision-making approach.

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Benoist F, Grand-Perret T: Co-translational degradation of apolipoprotein B100 by the proteasome is prevented by microsomal triglyceride transfer protein. Synchronized translation studies on HepG2 cells treated with an inhibitor of microsomal triglyceride transfer protein. J Biol Chem 1997;272:20435–20442. 81. Yeung SJ, Chen SH, Chan L: Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B. Biochemistry 1996;35:13843–13848. 82. Fisher EA, Zhou M, Mitchell DM, et al: The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70.

CH 2 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 109. 110. 111. 112. 113. Jiang X-C, Li Z, Liu R, et al: Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants. J Biol Chem 2005;280:18336–18340. Gillian-Daniel DL, Bates PW, Tebon A, Attie AD: Endoplasmic reticulum localization of the low-density lipoprotein receptor mediates presecretory degradation of apolipoprotein B.

Cardozo C, Wu X, Pan M, et al: The inhibition of microsomal triglyceride transfer protein activity in rat hepatoma cells promotes proteasomal and nonproteasomal degradation of apoprotein b100. Biochemistry 2002;41:10105–10114. Regulation and Clearance of Apolipoprotein B–Containing Lipoproteins 55. Nielsen LB, Sullivan M, Vanni-Reyes T, et al: The DNA sequences required for apolipoprotein B expression in the heart are distinct from those required for expression in the intestine. J MolCell Cardiol 1999;31:695–703.

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