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By Hilliard F. Seigler (auth.), H. F. Seigler (eds.)

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44 Table 1 continued. Author Reference Patient age Baruah Shanik Tallerman 49 50 37 70 51 63 56 Kherzi 17 72 42 * Presenting symptoms Site glans ulcer glans, prepuce swollen, tender penis pain, swelling glans & corpora phimosis, difficulty voiding prepuce swelling, change in color glans prepuce lesion Nodes + + + ? + + History previous melanoma of knee-probably secondary penile melanoma. disease [8]. Eight other patients are reported alive at two years [5, 9-15], of whom five eventually succumbed to their disease [5, 9, 10, 12, 14].

The diagnosis of secondary bladder melanoma is made cytoscopically and usually presents as blue-black patches or nodules found in any portion of the bladder. The lesions may be single or multiple. No case of secondary bladder melanoma has been a single isolated lesion, but rather is only a sign of widespread disease. Attempts at curative surgery have uniformly resulted in failure [118]. Most authors recommend transurethral resection for diagnosis and localized therapy [51, 53,111,119,123,124]. Recent reports of intra1esional BCG injection have shown some early success [125, 126].

J Pathol Bacteriol 84:307-311, 1962. 69. Best PV: A medulloblastoma-like tumour with melanin formation. J Pathol 110: 109-111, 1973. 70. Sung JH, Mastri AR and Segal EL: Melanotic medulloblastoma of the cerebellum. J Neuropathol Exp Neurol 32:437-445, 1973. 71. McCloskey JJ, Parker JC, Brooks WH and Blacker HM: Melanin as a component of cerebral gliomas: the melanotic cerebral ependymoma. Cancer 37:2373-2379, 1976. 72. Hahn JF, Sperber EE, Netsky MG: Melanotic neuroectodermal tumours of brain and skull.

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