By C. Braestrup, P. H. Andersen (auth.), Prof. Dr. Svein G. Dahl, Prof. Dr. Lars F. Gram (eds.)
This quantity collects the invited lectures and a few chosen contributions provided on the fifth overseas assembly on scientific Pharmacology in Psychiatry, which used to be held 26-30 June 1988 on the collage of Troms0, Norway. The 24 h of sunlight on the northernmost collage on the earth al lowed for lengthy, friendly and effective periods. The name of the convention in addition to some of the subject matters lined signify a continuation of 4 past meetings, the 1st held in Chicago in 1979 and arranged via the past due Earl U sdin and co-workers. the sooner meetings were documented in scientific Pharmacology in Psychiatry, edited via E. Usdin (Elsevier, long island, 1981), medical Pharmacology in Psychiatry. Neuroleptic and Antidepressant examine, edited through E. Usdin, S. G. Dahl, L. F. Gram and o. Lingjrerde (Macmillan Publishers Ltd., London, 1981), medical Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic hole, edited by means of LF. Gram, E. Usdin, S.G. Dahl, P. Kragh-Sorensen, P. L. Morselli and F. Sjoqvist (Macmillan Publishers Ltd., London, 1983), and scientific Pharmacology in Psychiatry. Selectivity in Psychotropic Drug motion - supplies or difficulties? edited through S. G. Dahl, L.F. Gram, S.M. Paul and W.Z. Potter (Psychopharmacology sequence three, Springer, Heidelberg, 1987).
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Extra resources for Clinical Pharmacology in Psychiatry: From Molecular Studies to Clinical Reality
Dose mol. kg-I. day-l ,u Fig. 1. Percentage of available striatal binding sites as a function of daily dosage of oral neuroleptics, expressed as chlorpromazine (CPZ) equivalents (Ilmol/kg per day) in 11 patients Targets for Neurotransmitter Receptor Research Using PET Scan 25 % ~WAlLABLE SITES 125 •• • 100 • -----------------------------------Q--------• • • 75 50 25 .. 2. Percentage of available striatal binding sites over time since withdrawal of neuroleptics. Seventeen PET studies after drug withdrawal are represented here, as well as seven performed during treatment.
J Cereb Blood Flow Metab [SuppI1]7:371 Persson A, Stone-Elander S, Pauli S, Sedvall G (1987) Saturation analysis ofbenzodiazepine receptor binding in the brain of healthy human subjects using llC-RO 15 1788 and PET. J Cereb Blood Flow Metab [SuppI1]7:344 Saelens JK, Simke JP, Neale SE, Weeks BJ, Selwyn M (1980) Effects of haloperidol and damphetamine on in vivo 3H-spiroperidol binding in the rat forebrain. Arch Int. Pharmacodyn Ther 246:98-107 Samson Y, Hantraye P, Baron JC, Soussaline F, Comar D, Maziere M (1985) Kinetics and displacement of l1C-RO 15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography.
Bioi Psychiatry 21:650-656 Targets for Neurotransmitter Receptor Research Using PET Scan 31 Krska J, Sampath G, Shah A, Sori SD (1986) Radio-receptor assay of serum neuroleptic levels in psychiatric patients. Br J Psychiatry 148: 187-193 Laduron PM, Janssen PFM, Leysen JE (1978) Characterization of specific in vivo binding of neuroleptic drugs in rat brain. Life Sci 23:581-586 Leysen JE (1984) Receptors for neuroleptic drugs. In: Burrows GD, Werry JS (eds) Advances in human psychopharmacology, vol 3.